Contaminants such as DNA, host cell proteins, leached protein A, aggregates, and viruses are efficiently removed. Capto adhere ImpRes Helps Solve Your Purification Problems The high selectivity of the anion multimodal ligand allows operation in a variety of process conditions to solve challenging purification problems. The multimodal anion exchanger ligand of Capto adhere ImpRes is immobilized to the base matrix and interacts with the target molecule through multiple types of interactions. Polishing can be performed in either bind and elute (binding) or flowthrough (nonbinding) modes. Capto adhere ImpRes is designed to allow effective MAb polishing in the second or third step of a purification scheme downstream of the protein A capture step. Allows separation of MAb charged variants.
Enables use of a platform approach to MAb process development. Efficient removal of aggregates, viruses, and main contaminants in MAb processes. High yields achieved through the high-resolution beads and selectivity of the ligand. Capto adhere ImpRes, 100 ml Capto adhere ImpRes is a strong anion exchange multimodal BioProcess chromatography medium (resin), designed to meet the demands of modern large-scale manufacturers, for high-resolution polishing of monoclonal antibodies (MAbs) and other biomolecules. Capto adhere ImpRes, 100 mlCapto adhere ImpRes, 100 mlĬapto adhere ImpRes is a multimodal anion exchange medium for intermediate purification and polishing of monoclonal antibodies after the Protein A capture step, giving the possibility to design a two step chromatographic downstream process The multimodal functionality gives a different selectivity compared with traditional ion exchange columns and it binds proteins at high or low ionic strength in combination with high resolution- and yield.
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